IROC Houston QA Center Located at the MD Anderson Cancer Center, this RT QA Center has experience interacting with approximately 1800 national and international research sites through its remote and on-site dosimetry quality audits, extensive RT credentialing programs, QA of brachytherapy treatments, and proton clinical trial QA program. Additionally, the center has experience with the design, implementation, and analysis of QA anthropomorphic phantoms for credentialing and maintains the only QA database of radiation oncology sites participating in NCI-sponsored research.  

IROC Ohio QA Center This imaging QA Center is located at The Ohio State University (OSU) Wexner Medical Center and James Comprehensive Cancer Center. Its extensive experience in all aspects of imaging in oncologic trials includes participation in the Imaging Response Assessment Teams, the Virtual Imaging Evaluation Workspace (VIEW) consortium, and the Oncology Biomarker Qualifying Initiative. With an extensive IT infrastructure focusing on commercial clinical system approaches supplemented by OSU Medical Center resources, this center has supported many national, international, and industry-sponsored resesarch projects.

IROC Rhode Island QA Center Located in Lincoln, RI and administered through the University of Massachusetts Medical School, this QA center has experience providing real-time on-site and remote review of imaging and RT objects to prevent research protocol deviations capable of invalidating trial results. It has developed a comprehensive fully validated informatics infrastructure for acquisition, management, and review of imaging and RT objects. With approximately 3000 new cases monitored each year, the IROC Rhode Island QA Center maintains more than 80,000 imaging datasets for 398 protocols from approximately 1500 participating sites.

IROC Philadelphia (RT) QA Center Located at the ACR Research Center in Philadelphia, this RT QA center has amassed extensive experience supporting a broad range of RT protocols of varying complexity and disease sites. Key strengths of this QA Center include its ability to collaborate with physicists, dosimetrists, and radiation oncologists in developing protocols and credentialing techniques; conduct case reviews using a centralized remote review system; and develop and standardize credentialing for IMRT and lung SBRT. In addition, it spearheaded QA support for trials involving advanced RT modalities, including 3D-CRT, IMRT, and IGRT. 

IROC Philadelphia (Imaging) QA Center Also located at the ACR Research Center in Philadelphia, this QA Center provides imaging trial support for NCTN studies involving PET, MR, and CT, and most disease sites. Key strengths include its experience with the VIEW consortium, standardized image management processes, and QA and analysis approaches across the NCTN system. Its extensive array of imaging analytic software and imaging IT infrastructure have led to an extensive and robust image archive and to a highly integrated set of procedures for international and national sites.

IROC St. Louis QA Center Located at Washington University, this RT QA Center has experience developing data exchange formats, data QA process, and an informatics infrastructure for transmission, receipt, and analysis of imaging and treatment planning data from participating sites. More than 15,000 patient data sets for more than 80 US and international clinical trial protocols have been captured by the center. Along with supporting the development and implementation of RT data standards, the IROC St. Louis QA Center also has experience developing consensus contouring atlases and supporting secondary analyses.