IROC is led by the IROC Executive Committee and managed by the IROC Management Committee, which oversees the uniform implementation of the five imaging and radiation oncology core quality assurance services across the National Clinical Trials Network. The IROC Advisory Committee ensures that input is received from a wide range of individuals who have an interest in IROC's successful operation. Additonally, IROC advances the science of quality assurance for imaging and radiation oncology clinical trials through the work of four subcommittees.